Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH.
AuthorsSchneider RA, Hu D, Rubenstein JL, Maden M, Helms JA,
JournalDevelopment
PubMed ID11526081
'Correlations between facial anomalies and brain defects are well characterized throughout the clinical literature, yet a developmental basis for this association has not been identified. We demonstrate that the frontonasal process, which gives rise to the mid- and upper face, and the forebrain are linked early in their morphogenesis by ... More
Ectopic expression of FGF-3 results in abnormal prostate and Wolffian duct development.
AuthorsChua SS, Ma ZQ, Gong L, Lin SH, DeMayo FJ, Tsai SY,
JournalOncogene
PubMed ID11896623
To evaluate the effects of FGF-3 expression in the prostate and male reproductive tract, we employed a bitransgenic system to target FGF-3 to these organs. We present a first study that ectopic FGF-3 expression resulted in exuberant hyperplasia of all bigenic prostatic lobes typified by epithelial stratification, cribiform structures and ... More