Restoration of blood flow by using continuous perimuscular infiltration of plasmid DNA encoding subterranean mole rat Spalax ehrenbergi VEGF.
AuthorsRoguin A, Avivi A, Nitecki S, Rubinstein I, Levy NS, Abassi ZA, Resnick MB, Lache O, Melamed-Frank M, Joel A, Hoffman A, Nevo E, Levy AP,
JournalProc Natl Acad Sci U S A
PubMed ID12672967
'The optimal vector, regulatory sequences, and method of delivery of angiogenic gene therapy are of considerable interest. The Spalax ehrenbergi superspecies live in subterranean burrows at low oxygen tensions and its tissues are highly vascularized. We tested whether continuous perimuscular administration of Spalax vascular endothelial growth factor (VEGF) DNA could ... More
Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality.
AuthorsKuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J,
JournalJ Biol Chem
PubMed ID12368298
'The amplified in breast cancer-3 (AIB3, ASC-2, RAP250, PRIP, TRBP, NRC, or NcoA6) gene is characterized as a cancer-amplified transcriptional coactivator for nuclear receptors, which include the peroxisome proliferator-activated receptor gamma (PPARgamma). To assess its biological function, we deleted the AIB3 gene in mice by homologous recombination. AIB3(+/-) mice are ... More
Recurrent amyloidoma of soft tissue with exuberant giant cell reaction.
AuthorsMukhopadhyay S, Damron TA, Valente AL,
JournalArch Pathol Lab Med
PubMed ID14632568
'Amyloidoma (localized tumorlike amyloidosis) in the soft tissues is rare. We present an instructive case of recurrent amyloidoma in the soft tissue of the ankle in a 45-year-old man with multiple surgical procedures and chronic osteomyelitis of the underlying bones. The lesion evaded diagnosis because of a florid giant cell ... More
Bizarre leiomyoma of the scrotum.
AuthorsKim NR, Sung CO, Han J,
JournalJ Korean Med Sci
PubMed ID12808340
Scrotal leiomyomas with atypical bizarre nuclei are rare, which might be misdiagnosed as malignant tumor. We describe a case of scrotal bizarre leiomyoma in a 65-yr-old man. The tumor was a 1 cm-sized, well circumscribed, oval mass arising from the tunica dartos muscle. Histologically, it was formed by whorling bundles ... More
Cellular characterization of human pluripotent stem cells.
AuthorsQuintanilla RH,
JournalMethods Mol Biol
PubMed ID23546756
Human pluripotent stem cells (PSCs), in particular induced PSCs, are very difficult to derive, grow, and bank. They require extensive amounts of resources and time to render them useful for basic and applied research. As the derivation methods, culture systems and tissues of origin differ, so does the quality of ... More
In vitro microvessels for the study of angiogenesis and thrombosis.
AuthorsZheng Y, Chen J, Craven M, Choi NW, Totorica S, Diaz-Santana A, Kermani P, Hempstead B, Fischbach-Teschl C, López JA, Stroock AD,
JournalProc Natl Acad Sci U S A
PubMed ID22645376
Microvascular networks support metabolic activity and define microenvironmental conditions within tissues in health and pathology. Recapitulation of functional microvascular structures in vitro could provide a platform for the study of complex vascular phenomena, including angiogenesis and thrombosis. We have engineered living microvascular networks in three-dimensional tissue scaffolds and demonstrated their ... More
Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide.
AuthorsFunk JL, Migliati E, Chen G, Wei H, Wilson J, Downey KJ, Mullarky PJ, Coull BM, McDonagh PF, Ritter LS,
JournalAm J Physiol Regul Integr Comp Physiol
PubMed ID12456385
Parathyroid hormone-related protein (PTHrP) is a multifunctional peptide that enhances blood flow in non-central nervous system (CNS) vascular beds by causing vasodilation. PTHrP expression is induced in non-CNS organs in response to ischemia. Experiments were therefore undertaken to determine whether PTHrP can be induced in brain in response to ischemic ... More
Metastatic juxtaglomerular cell tumor in a 52-year-old man.
AuthorsDuan X, Bruneval P, Hammadeh R, Fresco R, Eble JN, Clark JI, Vigneswaran WT, Flanigan RC, Picken MM,
JournalAm J Surg Pathol
PubMed ID15252319
Juxtaglomerular cell tumor is a rare renal neoplasm arising from the juxtaglomerular apparatus. Approximately 70 cases have been reported in the English literature since it was first described by Robertson et al in 1967. This tumor has been considered benign and resection has so far been curative. In this paper, ... More