Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.
Authors Wang Mai; Tan Zhongjia; Zhang Rong; Kotenko Sergei V; Liang Peng;
JournalJ Biol Chem
PubMed ID11706020
'Interleukin 24 (IL-24) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. Here we show that the human IL-24 is secreted by activated peripheral blood mononuclear cells and is the ligand for two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. The latter is also the ... More
Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes.
AuthorsBrown CR, Kennedy CJ, Delmar VA, Forbes DJ, Silver PA,
JournalGenes Dev
PubMed ID18316479
The nuclear localization of genes is intimately tied to their transcriptional status in Saccharomyces cerevisiae, with populations of both active and silent genes interacting with components of the nuclear envelope. We investigated the relationship between the mammalian nuclear pore and the human genome by generating high-resolution, chromosome-wide binding maps of ... More
Vascular Smooth Muscle alpha -Actin Gene Transcription during Myofibroblast Differentiation Requires Sp1/3 Protein Binding Proximal to the MCAT Enhancer.
Authors Cogan John G; Subramanian Sukanya V; Polikandriotis John A; Kelm Robert J Jr; Strauch Arthur R;
JournalJ Biol Chem
PubMed ID12110667
The conversion of stromal fibroblasts into contractile myofibroblasts is an essential feature of the wound-healing response that is mediated by transforming growth factor beta1 (TGF-beta1) and accompanied by transient activation of the vascular smooth muscle alpha-actin (SmalphaA) gene. Multiple positive-regulatory elements were identified as essential mediators of basal SmalphaA enhancer ... More