Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes.
AuthorsBrown CR, Kennedy CJ, Delmar VA, Forbes DJ, Silver PA,
JournalGenes Dev
PubMed ID18316479
The nuclear localization of genes is intimately tied to their transcriptional status in Saccharomyces cerevisiae, with populations of both active and silent genes interacting with components of the nuclear envelope. We investigated the relationship between the mammalian nuclear pore and the human genome by generating high-resolution, chromosome-wide binding maps of ... More