PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration.
AuthorsMathur M, Das S, Samuels HH,
JournalOncogene
PubMed ID12902986
'Papillary renal cell carcinomas are associated with chromosomal translocations involving the helix-loop-helix leucine-zipper region of the TFE3 gene on the X chromosome. These translocations lead to the expression of TFE3 chimeras of PRCC, RCC17, NonO and PSF (PTB-associated splicing factor). In this study, we explored the role of PSF-TFE3 fusion ... More
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
AuthorsIkeguchi M, Sakatani T, Ueta T, Fukuda K, Oka S, Hisamitsu K, Yamaguchi K, Tsujitani S, Kaibara N,
JournalJ Clin Pathol
PubMed ID11865007
The lysosomal protease cathepsin D has been reported to be associated with tumour progression in malignant tumours. Expression of the gene encoding cathepsin D is known to be stimulated by oestrogen in mammary cancer cells. Recent experiments revealed that a p53 DNA binding site is located in the promoter region ... More
beta-Tubulin-II expression strongly predicts outcome in patients receiving induction chemotherapy for locally advanced squamous carcinoma of the head and neck: a companion analysis of the TAX 324 trial.
AuthorsCullen KJ, Schumaker L, Nikitakis N, Goloubeva O, Tan M, Sarlis NJ, Haddad RI, Posner MR,
JournalJ Clin Oncol
PubMed ID19917838
TAX 324 was a phase III trial comparing induction chemotherapy (IC) with docetaxel, cisplatin, and fluorouracil (TPF) with cisplatin and fluorouracil (PF) followed by concomitant chemoradiotherapy in locally advanced squamous cell cancer of the head and neck (LASCCHN). This study evaluates a series of tumor markers in pretreatment biopsies from ... More
An associated classification of triple negative breast cancer: the risk of relapse and the response to chemotherapy.
AuthorsZhang J, Wang Y, Yin Q, Zhang W, Zhang T, Niu Y,
Journal
PubMed ID23826420
Triple negative breast cancer (TNBC) is heterogeneous and considered as an aggressive tumor. This study was to evaluate the associated classification and its correlations with prognosis and the response to chemotherapy in Chinese women. Four hundred and twenty-eight cases of invasive TNBC were involved in this study. The expression of ... More
Effects of maternally exposed food coloring additives on laryngeal histology in rats.
AuthorsBasak K, Doguç DK, Aylak F, Karadayi N, Gültekin F
Journal
PubMed ID24941295
Experimental reports showed carcinogenic effects of artificial food colors and additives (AFCAs) on many organs, including the head and neck region. We aimed to investigate the effect of AFCAs on laryngeal histomorphology and immunohistochemical expression in maternally exposed rats. "No observable adverse effect levels" of commonly used AFCAs as a ... More
Immunohistochemical investigation of the angiogenic proteins VEGF, HIF-1a and CD34 in invasive ductal carcinoma of the breast.
The expression of prognostic markers in cancer has become important in diagnostic routine and research. A high mitotic rate compromises the individual cell access to oxygen and nutrients, due to reduced blood supply. Cells undertake adaptive measures such as vascular endothelial growth factor (VEGF), expressed under the control of hypoxia-inducible ... More
Evaluation of prognostic factors in male breast cancer.
AuthorsTemmim L, Luqmani YA, Jarallah M, Juma I, Mathew M
JournalBreast
PubMed ID14965580
We conducted an analysis on 41 cases of male breast cancer (median age 54 y; range 25-82 y) in Kuwait. Most (51%) were stage II cancers with 65% arising in the left breast. There were 5 (12%) T1 tumours, 23 (56%) T2 tumours and 13 (32%) T3/T4 tumours. They were ... More