A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury.
AuthorsDib M, Zsengeller Z, Mitsialis A, Lu B, Craig S, Gerard C, Gerard NP,
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID19633070
The neuropeptide substance P manifests its biological functions through ligation of a G protein-coupled receptor, the NK1R. Mice with targeted deletion of this receptor reveal a preponderance of proinflammatory properties resulting from ligand activation, demonstrating a neurogenic component to multiple forms of inflammation and injury. We hypothesized that NK1R deficiency ... More