Epithelioid trophoblastic tumor of the broad ligament: a case report and review of the literature.
AuthorsKuo KT, Chen MJ, Lin MC,
JournalAm J Surg Pathol
PubMed ID15104307
'We report an epithelioid trophoblastic tumor, a recently delineated type of gestational trophoblastic tumor (GTT), discovered in the right broad ligament of a 41-year-old woman. The patient had gestational trophoblastic disease and was treated with methotrexate regimen 15 times 10 years earlier. The yellowish, spongy tumor with tiny hemorrhage spots ... More
Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells.
AuthorsMaeda T, Alexander CM, Friedl A,
JournalCancer Res
PubMed ID14744776
'Infiltrating carcinomas characteristically elicit a reactive stromal response, and accumulating evidence indicates that tumor stroma fibroblasts reciprocally promote tumor development and growth. The cell surface heparan sulfate proteoglycan, syndecan-1 (Sdc1), is thought to function as a coreceptor for growth factor and extracellular matrix interactions, and Sdc1 expression is induced in ... More
FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.
'Type 2 diabetes mellitus results from an inadequate adaptation of the functional pancreatic beta cell mass in the face of insulin resistance. Changes in the concentration of glucose play an essential role in the regulation of beta cell turnover. In human islets, elevated glucose concentrations impair beta cell proliferation and ... More
Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue.
'Cyclin D1 and p16INK4A are molecules with pivotal roles in cell cycle control and the development of diverse human cancers, and overexpression of cyclin D1 and loss of p16INK4A expression are common genetic events in head and neck squamous cell carcinoma. The prognostic significance of these molecular events at different ... More
Prevalence and classification of spontaneous mammary intraepithelial lesions in dogs without clinical mammary disease.
AuthorsMouser P, Miller MA, Antuofermo E, Badve SS, Mohammed SI,
JournalVet Pathol
PubMed ID20106771
'Mammary intraepithelial lesions (IELs) are noninvasive epithelial proliferations that include ductal hyperplasia (DH), atypical DH (ADH), and ductal carcinoma in situ (DCIS). In women, IELs are associated with increased risk of invasive breast cancer and form a basis for therapeutic decisions. Similarly, in female dogs, IELs are common in tumor-bearing ... More
Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro.
'Purpose. To characterize phenotypic differences between anterior and posterior corneal keratocytes after stimulation with the profibrotic agent transforming growth factor-beta1 (TGF-beta1) in vitro. Methods. Sixteen corneas from healthy felines were obtained immediately after death. Lamellar dissection was performed to separate the anterior and posterior stroma at approximately 50% depth either ... More
Prognostic value of Ki-67 expression in localized cutaneous malignant melanoma.
'The proliferative activity of some tumors is related to the development of metastatic disease and survival. Thus it could be used as a potential prognostic variable. The purpose of this study was to determine the prognostic value of the Ki-67 index and of a ' ... More
Individual and combined effects of subclinical doses of deoxynivalenol and fumonisins in piglets.
'Deoxynivalenol (DON) and fumonisins (FB) are the most frequently encountered mycotoxins produced by Fusarium species and most commonly co-occur in animal diets. These mycotoxins were studied for their toxicity in piglets on several parameters including plasma biochemistry, organ histopathology and immune response. Twenty-four 5-wk-old animals were randomly assigned to four ... More
Intermediate cells in human prostate epithelium are enriched in proliferative inflammatory atrophy.
Authorsvan Leenders GJ, Gage WR, Hicks JL, van Balken B, Aalders TW, Schalken JA, De Marzo AM,
JournalAm J Pathol
PubMed ID12707036
'Within the human prostate epithelium four cell populations can be discriminated based on their expression of keratins (K). Basal cells express high levels of K5 and K14, as well as p63, whereas they have very low levels of androgen receptor, prostate-specific antigen (PSA), K8, and K18. Luminal secretory cells lack ... More
Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.
AuthorsAaltonen V, Koivunen J, Laato M, Peltonen J,
JournalJ Histochem Cytochem
PubMed ID16517978
A total of 18 histological samples containing both transitional cell carcinoma (TCC) and normal urothelial epithelium were analyzed for protein kinase C (PKC)-alpha and -betaI expression, and for their phosphorylated substrates. The results showed an increased expression of PKC-alpha in 13 out of 18 samples and -betaI in 11 out ... More
Collagen density promotes mammary tumor initiation and progression.
AuthorsProvenzano PP, Inman DR, Eliceiri KW, Knittel JG, Yan L, Rueden CT, White JG, Keely PJ,
JournalBMC Med
PubMed ID18442412
Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, largely because no animal model has existed for studying breast tissue density. Importantly, regions of high breast density are associated with ... More
Rapid communication: renal apoptosis after shockwave application in rabbit model.
AuthorsCimentepe E, Eroglu M, Oztürk U, Bayrak O, Tuygun C, Acar A, Uzüm N, Unsal A,
JournalJ Endourol
PubMed ID17206909
To identify any apoptotic effect of shockwave lithotripsy (SWL) on renal tubular and glomerular cells. Thirty-five male New Zealand White rabbits were divided into five groups of seven rabbits each: I (control), II (sham), and III, IV, and GV (treated and sacrificed 1, 7, and 28 days after SWL, respectively). ... More
Peroxiredoxins in breast carcinoma.
AuthorsKarihtala P, Mäntyniemi A, Kang SW, Kinnula VL, Soini Y,
JournalClin Cancer Res
PubMed ID12960131
Peroxiredoxins (Prxs) are a novel group of peroxidases containing high antioxidant efficiency and some of them having also effects on cell differentiation and apoptosis. The mammalian Prx family has six distinct members located in various subcellular locations, including peroxisomes and mitochondria, places where oxidative stress is most evident. We examined ... More
Prognostic comparative study of S-phase fraction and Ki-67 index in breast carcinoma.
AuthorsPinto AE, André S, Pereira T, Nóbrega S, Soares J,
JournalJ Clin Pathol
PubMed ID11429427
To investigate the prognostic value of recently proposed flow cytometric S-phase fraction (SPF) variables (average SPF and SPF tertiles) compared with conventional SPF, and to compare the one with the best predictive value with the immunohistochemical Ki-67 index in breast carcinoma. A short term follow up study (median, 39.6 months) ... More
Tissue examination to monitor antiangiogenic therapy: a phase I clinical trial with endostatin.
AuthorsMundhenke C, Thomas JP, Wilding G, Lee FT, Kelzc F, Chappell R, Neider R, Sebree LA, Friedl A,
JournalClin Cancer Res
PubMed ID11705849
The purpose of this study was to determine the effect of the angiogenesis inhibitor endostatin on blood vessels in tumors and wound sites. In a Phase I dose escalation study, cancer patients were treated with daily infusions of human recombinant endostatin. Tumor biopsies were obtained prior to and 8 weeks ... More
Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature.
AuthorsDash RC, Provenzale JM, McComb RD, Perry DA, Longee DC, McLendon RE,
JournalArch Pathol Lab Med
PubMed ID10320149
From both epidemiologic and pathologic viewpoints, gangliogliomas exhibiting components of giant cell glioblastomas are extraordinary neoplasms. We report herein the case of a 6-year-old girl who presented initially with a World Health Organization grade IV anaplastic ganglioglioma (a mixed ganglion cell tumor-giant cell glioblastoma). Despite aggressive management, the patient died ... More
Immunohistochemical expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 in canine simple mammary gland adenocarcinomas.
AuthorsAl-Dissi AN, Haines DM, Singh B, Kidney BA
JournalCan Vet J
PubMed ID21197202
The expression of 5 markers associated with angiogenesis, proliferation, and apoptosis was studied in 26 canine simple mammary gland adenocarcinomas (SMGAs). The adenocarcinomas were graded histologically, and tissue sections were immunohistochemically stained for the expression of vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), intra-tumor microvessel density, and tumor proliferation ... More