Temporal and Geographic Clustering of Polyomavirus-Associated Olfactory Tumors in 10 Free-Ranging Raccoons (Procyon lotor).
AuthorsGiannitti F, Higgins RJ, Pesavento PA, Cruz FD, Clifford DL, Piazza M, Struckhoff AP, Valle LD, Bollen AW, Puschner B, Kerr E, Gelberg H, Mete A, McGraw S, Woods LW,
Journal
PubMed ID24045888
'Reports of primary nervous system tumors in wild raccoons are extremely rare. Olfactory tumors were diagnosed postmortem in 9 free-ranging raccoons from 4 contiguous counties in California and 1 raccoon from Oregon within a 26-month period between 2010 and 2012. We describe the geographic and temporal features of these 10 ... More
Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel.
AuthorsCarré M, André N, Carles G, Borghi H, Brichese L, Briand C, Braguer D,
JournalJ Biol Chem
PubMed ID12087096
'We have previously reported that anti-tubulin agents induce the release of cytochrome c from isolated mitochondria. In this study, we show that tubulin is present in mitochondria isolated from different human cancerous and non-cancerous cell lines. The absence of polymerized microtubules and cytosolic proteins was checked to ensure that this ... More
Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro.
AuthorsHansen MR, Zha XM, Bok J, Green SH,
JournalJ Neurosci
PubMed ID11264301
'We have shown previously that BDNF, neurotrophin-3 (NT-3), chlorphenylthio-cAMP (cpt-cAMP) (a permeant cAMP analog), and membrane depolarization promote spiral ganglion neuron (SGN) survival in vitro in an additive manner, depolarization having the greatest efficacy. Expression of both BDNF and of NT-3 is detectable in cultured SGNs after plating in either ... More
Specific neurotrophic factors support the survival of cortical projection neurons at distinct stages of development.
AuthorsCatapano LA, Arnold MW, Perez FA, Macklis JD,
JournalJ Neurosci
PubMed ID11698598
'Repair of specific neuronal circuitry in the neocortex may be possible via neural precursor transplantation or manipulation of endogenous precursors in situ. These approaches will almost certainly require a detailed understanding of the mechanisms that control survival and differentiation of specific neuronal lineages. Such analysis has been hampered by the ... More
Localization of connexin26 and connexin32 in putative CO(2)-chemosensitive brainstem regions in rat.
Recent studies have suggested that cell-to-cell coupling, which occurs via gap junctions, may play a role in CO(2) chemoreception. Here, we used immunoblot and immunohistochemical analyses to investigate the presence, distribution, and cellular localization of the gap junction proteins connexin26 (Cx26) and connexin32 (Cx32) in putative CO(2)-chemosensitive brainstem regions in ... More