Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis.
AuthorsAugusto D, Leteurtre E, De La Taille A, Gosselin B, Leroy X
JournalAppl Immunohistochem Mol Morphol
PubMed ID12051635
'Sex cord-stromal tumors represent approximately 4% of all testicular neoplasms. Leydig cell tumor (LCT) is the most common entity, followed by Sertoli cell tumor (SCT). Leydig cell tumor histologic diagnosis is usually easy, but occasional forms of LCT could mimic others neoplasms, especially SCT or variants of yolk sac tumor. ... More
Calretinin and inhibin are useful in separating adrenocortical neoplasms from pheochromocytomas.
AuthorsJorda M, De MB, Nadji M
JournalAppl Immunohistochem Mol Morphol
PubMed ID11893039
'Most adrenocortical neoplasms and pheochromocytomas can be diagnosed by a combination of clinical findings and morphologic features. Occasionally, however, this histologic differential diagnosis requires ancillary tests, such as immunohistochemistry. Both tumors are generally negative for epithelial markers but express synaptophysin. Inhibin and chromogranin are used for the diagnosis of adrenocortical ... More
Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.
AuthorsDrapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR, Hecht JL,
JournalCancer Res
PubMed ID15781627
'Among the genes most commonly identified in gene expression profiles of epithelial ovarian carcinomas (EOC) is the gene for human epididymis protein 4 (HE4). To ascertain its clinical utility, we did a comprehensive assessment of HE4 protein expression in benign and malignant ovarian and nonovarian tissues by immunohistochemistry. In comparison ... More
Florid decidual reaction mimicking gastrointestinal malignancy in a primipara woman.
AuthorsRodriguez FJ, Abraham SC, Sendelbach KM, Nascimento AG
JournalHistopathology
PubMed ID16842249
Re-evaluation of histological diagnoses of malignant mesothelioma by immunohistochemistry.
AuthorsSandeck HP, Røe OD, Kjærheim K, Willén H, Larsson E
JournalDiagn Pathol
PubMed ID20602796
In order to provide reliable tissue material for malignant mesothelioma (MM) studies, we re-evaluated biopsies and autopsy material from 61 patients with a diagnosis of MM from the period of 1980-2002. ... More
Corticomedullary mixed tumor of the adrenal gland with concurrent adrenal myelolipoma.
AuthorsChu AY, LiVolsi VA, Fraker DL, Zhang PJ
JournalArch Pathol Lab Med
PubMed ID12873195
We report the case of a corticomedullary mixed tumor of the adrenal gland in a 55-year-old woman with a left adrenal mass who presented with mild symptoms of Cushing syndrome and an elevated urinary cortisol level. The patient underwent a left adrenalectomy. A well-circumscribed 2.5-cm mass, composed of an admixture ... More
The unique simultaneous occurrence of granular cell tumor, gastrointestinal stromal tumor, and gastric adenocarcinoma.
AuthorsSailors JL, French SW
JournalArch Pathol Lab Med
PubMed ID15859656
Granular cell tumors are generally benign oncocytoid lesions of schwannian origin that are often incidental findings in many locations. Gastrointestinal stromal tumors occur in older adults and express the c-Kit protein (CD117). Both of these tumors have been described in association with many other entities; however, they have never been ... More
Calretinin expression in ameloblastomas.
AuthorsAltini M, Coleman H, Doglioni C, Favia G, Maiorano E,
JournalHistopathology
PubMed ID10931215
AIMS: Calretinin is a 29-kDa calcium-binding protein which is expressed in the central and peripheral nervous systems as well as in many other normal and pathological human tissues. The objective of this study was to determine whether calretinin was expressed in the epithelium of ameloblastomas. METHODS AND RESULTS: Twenty-seven cases ... More
Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor.
AuthorsDeVilliers P, Liu H, Suggs C, Simmons D, Daly B, Zhang S, Raubenheimer E, Larsson A, Wright T
JournalAm J Surg Pathol
PubMed ID18223328
Ameloblastoma is a benign, locally aggressive epithelial odontogenic tumor that has the potential to become malignant and produce metastasis to distant sites such as lungs and kidneys. The histologic presentation can be, in some instances, mistaken for keratocystic odontogenic tumor (KCOT) (formerly known as odontogenic keratocyst). The expression of calretinin ... More
Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms.
AuthorsKojika M, Ishii G, Yoshida J, Nishimura M, Hishida T, Ota SJ, Murata Y, Nagai K, Ochiai A
JournalMod Pathol
PubMed ID19648882
There are only a few immunohistochemical markers that are useful for differentiating thymic carcinomas from type B3 thymomas. The purpose of this study is to examine the additional markers that would be useful for differentiating between thymic carcinoma and thymoma type B3. We performed a tissue microarray analysis of surgically ... More
Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy.
AuthorsMaire CL, Ramkissoon S, Hayashi M, Haidar S, Ramkissoon L, DiTomaso E, Ligon KL
Journal
PubMed ID24395742
Therapeutic modulation of phosphatidylinositol 3-kinase (PI3K)/PTEN signaling is currently being explored for multiple neurological indications including brain tumors and seizure disorders associated with cortical malformations. The effects of PI3K/PTEN signaling are highly cell context dependent but the function of this pathway in specific subsets of neural stem/progenitor cells generating oligodendroglial ... More