Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet.
AuthorsYang W, Bancroft L, Nicholas C, Lozonschi I, Augenlicht LH
JournalCancer Res
PubMed ID12941825
Mice with a targeted inactivation of both alleles of the cyclin-dependent kinase inhibitor p27(kip1) developed both small and large intestinal adenomas when fed a control AIN-76A diet. A Western-style diet that is high in fat and phosphate and low in calcium and vitamin D was also able to initiate adenoma ... More
The effect of Longan seed polyphenols on colorectal carcinoma cells.
AuthorsChung YC, Lin CC, Chou CC, Hsu CP,
JournalEur J Clin Invest
PubMed ID20561027
'Polyphenol-rich longan seed extract (LSP) is a free radical scavenger and antioxidant. However, the effect of LSP on the growth of human colorectal carcinoma cells (CRC) has not yet been evaluated. Polyphenols of longan seeds were extracted and measured by colorimetry. Four CRC cell lines (Colo 320DM, SW480, HT-29 and ... More
Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat.
AuthorsPaulsen JE, Løberg EM, Olstørn HB, Knutsen H, Steffensen IL, Alexander J,
JournalCancer Res
PubMed ID15665287
'We evaluated the role of aberrant crypt foci (ACF) as biomarkers of colon cancer by studying the sequential development (6-28 weeks) from early lesion to tumor in the colon of azoxymethane-exposed F344 rats (15 mg/kg bw x 2). Surface examination of unsectioned methylene blue-stained colon preparations, transilluminated in the inverse ... More
CD5+ follicle center lymphoma. Immunophenotyping detects a unique subset of "floral" follicular lymphoma.
AuthorsTiesinga JJ, Wu CD, Inghirami G
JournalAm J Clin Pathol
PubMed ID11338480
'The "floral" variant of follicle center lymphoma (FCL) may be confused with progressive transformation of germinal centers or lymphocyte predominance Hodgkin lymphoma. Immunohistochemistry and gene rearrangement studies are usually sufficient to differentiate among these entities. We present 11 cases of floral FCL that were evaluated at our institution by flow ... More
Epithelial Urinary Bladder Tumors From Cows With Enzootic Hematuria: Structural and Cell Cycle-Related Protein Expression.
Thirty-nine epithelial bladder tumor samples from 37 animals affected with bovine enzootic hematuria (BEH) were selected for immunohistochemical studies. The expression of structural proteins such as uroplakin III (UPIII) and cytokeratin 7 (CK7) and the cell cycle-related proteins cyclin D1 and p53 were evaluated in urothelial papillomas and carcinomas. Loss ... More
Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma.
AuthorsNorth JP, Kageshita T, Pinkel D, LeBoit PE, Bastian BC
JournalJ Invest Dermatol
PubMed ID18323782
Primary melanoma can recur at the excision site if not excised with a safety margin of surrounding uninvolved skin. To characterize the nature of residual melanoma in the skin surrounding primary tumors targeted by safety margins, we used array comparative genomic hybridization and fluorescent in situ hybridization to detect and ... More