Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis.
AuthorsHolzinger A, Dingle S, Bejarano PA, Miller MA, Weaver TE, DiLauro R, Whitsett JA,
JournalHybridoma
PubMed ID9064286
'Thyroid transcription factor-1 (TTF-1), a member of the NKx2 family of homeodomain transcription factors, is expressed in epithelial cells of the thyroid gland and the lung. To produce monoclonal antibodies specific for TTF-1, the polypeptide was expressed in E. coli and purified utilizing affinity chromatography of a polyhistidine-tagged TTF-1 fusion ... More
Estrogen replacement in female lung cancer during gefitinib therapy.
AuthorsWang PH, Wang HC, Tsai CC
JournalJpn J Clin Oncol
PubMed ID19692419
Estrogen receptor (ER) has been detected in some specimens of lung cancer. Estrogen has an effect on the growth of lung cancer cell lines. An inverse relationship between ER and epithelial growth factor receptor (EGFR) was reported in pre-clinical data. A 70-year-old female with lung adenocarcinoma, who achieved a partial ... More