Morphologic evaluation and integrin expression profile of renal tubular cells cultured from percutaneous renal biopsy specimen.
AuthorsKim JS, Hwang HZ, Yeo SH, Ko SW, Song SM, Kim YK, Kim DJ, Oh HY, Choi HY, Kim MK, Toru S, Kohsaka T, Kim Y, Jin DK
JournalRen Fail
PubMed ID11256526
'Kidney biopsy is an indispensible procedure for making a pathologic diagnosis of renal diseases by fixing and staining the biopsy specimen. However, it is not a routine procedure to culture the cells from a renal biopsy specimen directly, or to utilize the cultured cells for any kind of diagnostic or ... More
Microcystic stromal tumor of the ovary with mutation in exon 3 of ß-catenin: a case report.
AuthorsKang YN, Cho CH, Kwon SY
Journal
PubMed ID25675179
'Microcystic stromal tumor of the ovary is a very rare ovarian tumor with distinctive microcystic histologic features and a characteristic immunophenotype of stromal tumor. However, its origin, tumor pathogenesis, and prognosis have not been well established until now. We report a very unusual case of a microcystic stromal tumor of ... More
Matrix Metalloproteinases 2 and 9 and E-Cadherin Expression in the Endometrium During the Implantation Window of Infertile Women Before In Vitro Fertilization Treatment.
'Objective:To evaluate the expression of endometrial matrix metalloproteinases (MMPs) 2 and 9 and E-cadherin in peri-implantation phase of infertile women who have undergone in vitro fertilization (IVF) cycles.Methods:This prospective study included 51 patients who underwent endometrial biopsy during the receptive phase in a menstrual cycle prior to IVF treatment. The ... More
Diffuse expression of MUC 1 in metastases of renal clear cell carcinoma as a possible therapeutic target for renal cancer.
Endothelium-coated tumor clusters are associated with poor prognosis and micrometastasis of hepatocellular carcinoma after resection.
AuthorsDing T, Xu J, Zhang Y, Guo RP, Wu WC, Zhang SD, Qian CN, Zheng L
JournalCancer
PubMed ID21480209
Distinct morphologic features of microvascular endothelium exist in tumor tissues. The objective of this study was to investigate the prognostic value of endothelium-coated tumor clusters (ECTCs) in hepatocellular carcinoma (HCC). ... More
Sulfated HNK-1 epitope in developing and mature kidney: a new marker for thin ascending loop of Henle and tubular injury in acute tubular necrosis.
AuthorsAllory Y, Commo F, Boccon-Gibod L, Sibony M, Callard P, Ronco P, Debiec H,
JournalJ Histochem Cytochem
PubMed ID16401697
The HNK-1 carbohydrate epitope is a 3-sulfo-glucuronyl residue attached to lactosamine structures on glycoproteins, proteoglycans, or glycolipids mostly expressed in the nervous system. Here, using monoclonal antibodies against the sulfated HNK-1 carbohydrate epitope, we first examined its distribution in developing and adult kidneys, then its expression in kidneys with tubular ... More
Differential expression of E-cadherin and beta catenin in primary and metastatic Wilms's tumours.
AuthorsAlami J, Williams BR, Yeger H,
JournalMol Pathol
PubMed ID12890743
BACKGROUND: The E-cadherin-catenin adhesion complex is crucial for intercellular adhesiveness and maintenance of tissue architecture. Its impairment is associated with poorly differentiated phenotype and increased invasiveness of carcinomas. AIMS: To evaluate E-cadherin, beta catenin, gamma catenin, and ezrin expression and its relation to histopathological features of primary and metastatic Wilms's ... More
Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma.
AuthorsGu MJ, Choi JH,
Journal
PubMed ID24062361
The aim of this study was to evaluate the epithelial-mesenchymal transition (EMT) and to assess its prognostic significance in intrahepatic cholangiocarcinoma. We performed immunohistochemical stainings for E-cadherin, ß-catenin, vimentin and fibronectin in a total of 85 cases. Expression of vimentin and reduced expression of E-cadherin were found to show correlation ... More
Histological and immunohistochemical identification of atypical ductal mammary hyperplasia as a preneoplastic marker in dogs.
AuthorsFerreira E, Gobbi H, Saraiva BS, Cassali GD
JournalVet Pathol
PubMed ID21282668
This study describes and evaluates the morphological and molecular relationship between canine mammary ductal hyperplasias with atypia and canine mammary neoplasias. Ductal hyperplasia was identified in association with malignant neoplasia in 56 of the 115 cases (48,8%), and although ductal hyperplasia without atypia was the type most frequently noted in ... More
Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus.
AuthorsLuo Y, Radice GL
JournalJ Cell Sci
PubMed ID12640032
The strong coordinated contraction of heart muscle is dependent on the correct alignment and connection of the myofibrils across the plasma membrane. Previous studies indicate that N-cadherin is involved in cardiac myocyte adhesion and myofibrillogenesis. To investigate whether N-cadherin is specifically required for normal myocyte structure and function, we cultured ... More
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation.
AuthorsBartosch C, Mendes N, Rios E, Rodrigues M, Eloy C, Reis CA, Amendoeira I
Journal
PubMed ID26092598
Signet-ring cells are relatively common in breast cancers but are frequently overlooked. Although previously defined as a subtype of mucin producing carcinomas, breast carcinomas with signet-ring cell (SRC) differentiation nowadays are not considered a distinct entity. The objective of the present study was to characterize the morphological features and mucin ... More
Methyl deficient diet aggravates experimental colitis in rats.
AuthorsChen M, Peyrin-Biroulet L, George A, Coste F, Bressenot A, Bossenmeyer-Pourie C, Alberto JM, Xia B, Namour B, Guéant JL
JournalJ Cell Mol Med
PubMed ID21199330
Inflammatory bowel diseases (IBD) result from complex interactions between environmental and genetic factors. Low blood levels of vitamin B12 and folate and genetic variants of related target enzymes are associated with IBD risk, in population studies. To investigate the underlying mechanisms, we evaluated the effects of a methyl-deficient diet (MDD, ... More