'Mutations in the plakoglobin (JUP) gene have been identified in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients. However, the mechanisms underlying plakoglobin dysfunction involved in the pathogenesis of ARVC remain poorly understood. Plakoglobin is a component of both desmosomes and adherens junctions located at the intercalated disc (ICD) of cardiomyocytes, where ... More
Dysregulation of ß-catenin is an independent predictor of oncologic outcomes in patients with clear cell renal cell carcinoma.
AuthorsKrabbe LM, Westerman ME, Bagrodia A, Gayed BA, Darwish OM, Haddad AQ, Khalil D, Kapur P, Sagalowsky AI, Lotan Y, Margulis V
Journal
PubMed ID24291548
'Epithelial-to-mesenchymal transition is thought to have a crucial role in cancer progression and metastatic egress. We evaluated the association of ß-catenin, an important mediator of epithelial-to-mesenchymal transition, with pathological parameters and oncologic outcomes in patients with clear cell renal cell carcinoma.' ... More
Alteration of the ß-catenin pathway in spiradenoma.
AuthorsIm M, Kim DH, Park JS, Chung H, Lee Y, Kim CD, Seo YJ, Lee JH
JournalJ Cutan Pathol
PubMed ID21518380
'Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the ß-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This study was performed to assess ... More
Expression of Wnt and TGF-ß pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness.
AuthorsParviainen H, Schrade A, Kiiveri S, Prunskaite-Hyyryläinen R, Haglund C, Vainio S, Wilson DB, Arola J, Heikinheimo M
Journal
PubMed ID23866946
'Factors controlling benign and malignant adrenocortical tumorigenesis are largely unknown, but several mouse models suggest an important role for inhibin-alpha (INHA). To show that findings in the mouse are relevant to human tumors and clinical outcome, we investigated the expression of signaling proteins and transcription factors involved in the regulation ... More
Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of beta catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy.
AuthorsRamburan A, Oladiran F, Smith C, Hadley GP, Govender D,
JournalJ Clin Pathol
PubMed ID15623481
To determine whether microsatellite mutations of the adenomatous polyposis coli (APC) gene have pathological or prognostic significance in nephroblastomas and to correlate APC alterations with beta catenin immunoexpression. One hundred nephroblastomas were analysed, 83 of which received preoperative chemotherapy. Normal and tumour DNA was isolated using standard proteinase K digestion ... More
Leuprorelin acetate affects adhesion molecule expression in human prostate cancer cells.
AuthorsAngelucci C, Lama G, Iacopino F, Sica G,
JournalInt J Oncol
PubMed ID21479359
Reduced cell-cell adhesion allows malignant epithelial cells to invade the basal membrane and penetrate the stroma. This implies the potential of the cells to escape from the primary tumor as well as spreading ability. Herein, we investigated the effects of leuprorelin acetate (LA), a GnRH agonistic analogue, alone or in ... More
Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma.
AuthorsGu MJ, Choi JH,
Journal
PubMed ID24062361
The aim of this study was to evaluate the epithelial-mesenchymal transition (EMT) and to assess its prognostic significance in intrahepatic cholangiocarcinoma. We performed immunohistochemical stainings for E-cadherin, ß-catenin, vimentin and fibronectin in a total of 85 cases. Expression of vimentin and reduced expression of E-cadherin were found to show correlation ... More
Quantitative fluorescence imaging analysis for cancer biomarker discovery: application to beta-catenin in archived prostate specimens.
AuthorsHuang D, Casale GP, Tian J, Wehbi NK, Abrahams NA, Kaleem Z, Smith LM, Johansson SL, Elkahwaji JE, Hemstreet GP,
JournalCancer Epidemiol Biomarkers Prev
PubMed ID17623804
The surprising disparity between the number of protein-encoding genes ( approximately 30,000) in the human genome and the number of proteins ( approximately 300,000) in the human proteome has inspired the development of translational proteomics aimed at protein expression profiling of disease states. Translational proteomics, which offers the promise of ... More
Plexiform fibromyxoma (plexiform angiomyxoid myofibroblastic tumor) of stomach: an unusual presentation as a fistulating abscess.
AuthorsLee PW, Yau DT, Lau PP, Chan JK
Journal
PubMed ID23794494
Plexiform fibromyxoma (plexiform angiomyxoid myofibroblastic tumor) is a rare benign mesenchymal tumor of stomach. The plexiform growth of bland-looking spindly cells in a richly vascularized fibromyxoid stroma is distinctive. The described cases are solid tumors associated with ulceration, with the patients presenting with symptoms related to the ulcer or mass ... More