Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter Pylori eradication and detection of API2-MALT1 fusion.
AuthorsInagaki H, Nakamura T, Li C, Sugiyama T, Asaka M, Kodaira J, Iwano M, Chiba T, Okazaki K, Kato A, Ueda R, Eimoto T, Okamoto S, Sasaki N, Uemura N, Akamatsu T, Miyabayashi H, Kawamura Y, Goto H, Niwa Y, Yokoi T, Seto M, Nakamura S,
JournalAm J Surg Pathol
PubMed ID15577674
'Gastric MALT lymphoma shows unique features including regression by Helicobacter pylori eradication and API2-MALT1 fusion. We performed a molecular and clinicopathologic study for 115 cases. All eradication-responsive cases were devoid of API2-MALT1 fusion. All tumors positive for the fusion and all negative for H. pylori infection were nonresponsive to the ... More
t(1;14) and t(11;18) in the differential diagnosis of Waldenström's macroglobulinemia.
AuthorsYe H, Chuang SS, Dogan A, Isaacson PG, Du MQ,
JournalMod Pathol
PubMed ID15143341
'Waldenström''s macroglobulinemia is caused by several B-cell proliferative disorders including lymphoplasmacytic lymphoma, marginal zone B-cell lymphoma, B-cell chronic lymphocytic leukemia and multiple myeloma. Differential diagnosis between lymphoplasmacytic lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue is particularly difficult as there is a considerable overlap in histological presentation. We ... More
Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1.
'API2-MALT1 fusion and aneuploidy are common chromosomal abnormalities in MALT lymphoma. In studying their incidence and relationship in primary pulmonary MALT lymphomas, a translocation involving MALT1 and IGH was also identified. In all, 28 primary pulmonary MALT lymphomas were studied by fluorescence in situ hybridization using an API2-MALT1 probe and ... More