Principles of 3' splice site selection and alternative splicing for an unusual group II intron from Bacillus anthracis.
AuthorsRobart AR, Montgomery NK, Smith KL, Zimmerly S,
JournalRNA
PubMed ID15100440
We investigated the self-splicing properties of two introns from the bacterium Bacillus anthracis. One intron (B.a.I1) splices poorly in vitro despite having typical structural motifs, while the second (B.a.I2) splices well while having apparently degenerated features. The spliced exons of B.a.I2 were sequenced, and splicing was found to occur at ... More
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.
Authors Yeap Bu B; Voon Dominic C; Vivian Julian P; McCulloch Ross K; Thomson Andrew M; Giles Keith M; Czyzyk-Krzeska Maria F; Furneaux Henry; Wilce Matthew C J; Wilce Jackie A; Leedman Peter J;
JournalJ Biol Chem
PubMed ID12011088
The androgen receptor (AR) mediates androgen action and plays a central role in the proliferation of specific cancer cells. We demonstrated recently that AR mRNA stability is a major determinant of AR gene expression in prostate and breast cancer cells and that androgens differentially regulate AR mRNA decay dependent on ... More