Contact-dependent endothelial class II HLA gene activation induced by NK cells is mediated by IFN-gamma-dependent and -independent mechanisms.
AuthorsWatson CA, Petzelbauer P, Zhou J, Pardi R, Bender JR,
JournalJ Immunol
PubMed ID7897208
NK lymphocytes adhere avidly to allogeneic endothelial cells (ECs) and induce their membrane expression of MHC class II Ags in vitro. Endothelial class II expression augments EC-driven CD4+ T cell proliferation in vitro, and may amplify T cell recruitment and clonal expansion in vivo. Using an ex vivo lymphocyte-skin organ ... More