Sp3 Represses Gene Expression via the Titration of Promoter-specific Transcription Factors.
Authors: Kennett Sarah B; Moorefield K Scott; Horowitz Jonathan M;
Journal:J Biol Chem
PubMed ID:11773047
'We have determined previously that Sp3 encodes three distinct gene products as follows: a full-length protein (Sp3) that is an activator of transcription and two isoforms (M1 and M2) derived via internal translational initiation that function as transcriptional repressors. To identify amino acids and functions required for transcriptional repression, we ... More
Both DNA and histone fold sequences contribute to archaeal nucleosome stability.
Authors: Bailey Kathryn A; Marc Frederic; Sandman Kathleen; Reeve John N;
Journal:J Biol Chem
PubMed ID:11751933
'The roles and interdependence of DNA sequence and archaeal histone fold structure in determining archaeal nucleosome stability and positioning have been determined and quantitated. The presence of four tandem copies of TTTAAAGCCG in the polylinker region of pLITMUS28 resulted in a DNA molecule with increased affinity (DeltaDeltaG of approximately 700 ... More
Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells.
Authors: Muenzner Petra; Billker Oliver; Meyer Thomas F; Naumann Michael;
Journal:J Biol Chem
PubMed ID:11751883
'The human-specific pathogen Neisseria gonorrhoeae expresses opacity-associated (Opa) protein adhesins that bind to various members of the carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family. In this study, we have analyzed the mechanism underlying N. gonorrhoeae-induced CEACAM up-regulation in epithelial cells. Epithelial cells represent the first barrier for the microbial pathogen. ... More
Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture.
Authors: Stimson Krista M; Vertino Paula M;
Journal:J Biol Chem
PubMed ID:11733524
'Aberrant methylation of CpG-dense islands in the promoter regions of genes is an acquired epigenetic alteration associated with the silencing of tumor suppressor genes in human cancers. In a screen for endogenous targets of methylation-mediated gene silencing, we identified a novel CpG island-associated gene, TMS1, which is aberrantly methylated and ... More
Functional coadaptation between cytochrome c and cytochrome c oxidase within allopatric populations of a marine copepod.
Authors: Rawson Paul D; Burton Ronald S;
Journal:Proc Natl Acad Sci U S A
PubMed ID:12271133
'Geographically isolated populations may accumulate alleles that function well on their own genetic backgrounds but poorly on the genetic backgrounds of other populations. Consequently, interpopulation hybridization may produce offspring of low fitness as a result of incompatibilities arising in allopatry. Genes participating in these epistatic incompatibility systems remain largely unknown. ... More