Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes.
AuthorsZhang T, Qi ST, Huang L, Ma XS, Ouyang YC, Hou Y, Shen W, Schatten H, Sun QY
Journal
PubMed ID26125114
'Cyclin B3 is a relatively new member of the cyclin family whose functions are little known. We found that depletion of cyclin B3 inhibited metaphase-anaphase transition as indicated by a well-sustained MI spindle and cyclin B1 expression in meiotic oocytes after extended culture. This effect was independent of spindle assembly ... More
The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress.
AuthorsLee MH, Wang L, Chang ZF,
Journal
PubMed ID24561807
'In quiescent fibroblasts, the expression levels of cytosolic enzymes for thymidine triphosphate (dTTP) synthesis are down-regulated, causing a marked reduction in the dTTP pool. In this study, we provide evidence that mitochondrial thymidylate synthesis via thymidine kinase 2 (TK2) is a limiting factor for the repair of ultraviolet (UV) damage ... More
Pemetrexed Plus Cisplatin Versus Gemcitabine Plus Cisplatin According to Thymidylate Synthase Expression in Nonsquamous Non-Small-Cell Lung Cancer: A Biomarker-Stratified Randomized Phase II Trial.
AuthorsSun JM, Ahn JS, Jung SH, Sun J, Ha SY, Han J, Park K, Ahn MJ
Journal
PubMed ID26124486
We investigated whether thymidylate synthase (TS) expression is a predictive marker for the clinical outcome of pemetrexed/cisplatin in patients with nonsquamous non-small-cell lung cancer.
Features of potentially predictive biomarkers of chemotherapeutic efficacy in small cell lung cancer.
One-size-fits-all chemotherapy does not improve survival in patients with small cell lung cancer (SCLC). Excision repair cross-complementing group 1 (ERCC1), ribonucleotide reductase 1 (RRM1), thymidylate synthase (TS), and topoisomerase 2alpha (Topo2alpha) expression levels are predictive of chemotherapeutic efficacy in some malignancies. Our aim was to determine the expression levels of ... More
Treatment of metastatic sarcoma to the liver with bland embolization.
The authors evaluated the impact of bland particle embolization on survival in patients with metastatic sarcoma to the liver. Twenty-four patients with liver-dominant metastases from sarcoma were treated with particle embolization from 1996 to 2002. Primary tumors included 16 gastrointestinal stromal tumors (GISTs), 7 intestinal leiomyosarcomas, and 1 liposarcoma. Thirteen ... More