Development of a DNA-labeling system for array-based comparative genomic hybridization.
AuthorsLieu PT, Jozsi P, Gilles P, Peterson T,
JournalJ Biomol Tech
PubMed ID16030317
'Chromosomal amplifications and deletions are critical components of tumorigenesis and DNA copy-number variations also correlate with changes in mRNA expression levels. Genome-wide microarray comparative genomic hybridization (CGH) has become an important method for detecting and mapping chromosomal changes in tumors. Thus, the ability to detect twofold differences in fluorescent intensity ... More
Genomic Islands of Speciation in Anopheles gambiae.
AuthorsTurner TL, Hahn MW, Nuzhdin SV,
JournalPLoS Biol
PubMed ID16076241
'The African malaria mosquito, Anopheles gambiae sensu stricto (A. gambiae), provides a unique opportunity to study the evolution of reproductive isolation because it is divided into two sympatric, partially isolated subtaxa known as M form and S form. With the annotated genome of this species now available, high-throughput techniques can ... More