Signet-ring cell carcinoma (SRCC) is a poorly differentiated mucin-producing adenocarcinoma that may arise from many different organs, but all SRCCs share identical morphology. It is not possible to differentiate sites of origin for metastatic SRCC based on morphology alone. Mucins are high-molecular-weight glycoproteins differentially expressed in glandular epithelia and in ... More
Expression of mucins on the mucosal surface of lungs of 4-week-old pigs.
AuthorsKim CH, Lee K, Han K, Oh Y, Kim D, Seo HW, Park C, Ha MK, Kim SH, Cho KD, Lee BH, Chae C
JournalVet Res Commun
PubMed ID21331513
The aim of this study was to determine the immunoreactivity of normal small bronchial, bronchiolar, respiratory bronchiolar, and interalveolar epithelium using antibodies to six mucins: MUC1, MUC2, MUC4, MUC5AC, MUC5B, and MUC6. The large, gel-forming secreted mucins MUC2, MUC5AC, and MUC5B were widely expressed in the lower respiratory tract. The ... More
MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications.
AuthorsHandra-Luca A, Lamas G, Bertrand JC, Fouret P,
JournalAm J Surg Pathol
PubMed ID15958852
We determined whether immunostaining for mucins could provide a better characterization of salivary gland mucoepidermoid carcinoma (MEC). We investigated 63 MECs by immunohistochemistry for MUC1, MUC2, MUC4, and MUC5AC. Mucin expressing cell types and labeling patterns were recorded. The results were compared with microscopic grade, tumor-associated lymphoid infiltrate, mucin expression ... More
Vocal fold ion transport and mucin expression following acrolein exposure.
AuthorsLevendoski EE, Sivasankar MP
Journal
PubMed ID24648011
The vocal fold epithelium is exposed to inhaled particulates including pollutants during breathing in everyday environments. Yet, our understanding of the effects of pollutants on vocal fold epithelial function is extremely limited. The objective of this study was to investigate the effect of the pollutant acrolein on two vocal fold ... More