'The salivary glands of female mosquitoes contain a variety of bioactive substances that assist their blood-feeding behavior. Here, we report a salivary protein of the malarial vector mosquito, Anopheles stephensi, that inhibits activation of the plasma contact system. This factor, named hamadarin, is a 16-kDa protein and a major component ... More
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.
Authors Gomes M D; Lecker S H; Jagoe R T; Navon A; Goldberg A L;
JournalProc Natl Acad Sci U S A
PubMed ID11717410
'Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway. To identify key factors in this process, we have used cDNA microarrays to compare normal and atrophying muscles and found a unique gene fragment that ... More
New mammalian chloride channel identified by expression cloning.
AuthorsPaulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D
JournalNature
PubMed ID1313151
Ion channels selectively permeable to chloride ions regulate cell functions as diverse as excitability and control of cell volume. Using expression cloning techniques, a complementary DNA from an epithelial cell line has been isolated, sequenced and its putative structure examined by site-directed mutagenesis. This cDNA, encoding a 235-amino- acid protein, ... More
FEEL-1, a Novel Scavenger Receptor with in Vitro Bacteria-binding and Angiogenesis-modulating Activities.
Authors Adachi Hideki; Tsujimoto Masafumi;
JournalJ Biol Chem
PubMed ID12077138
Employing the expression cloning technique, we cloned a novel scavenger receptor that is structurally unrelated to other scavenger receptors. The cloned receptor contained fasciclin (Fas-1), epidermal growth factor (EGF)-like, laminin-type EGF-like, and link domains. Based on the domain structures, we temporarily named it FEEL-1 (fasciclin, EGF-like, laminin-type EGF-like, and link ... More