Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils.
AuthorsMeru N, Jung A, Baumann I, Niedobitek G,
JournalBlood
PubMed ID11781235
V(D)J recombination in lymphocytes is mediated by 2 recombination-activating genes, RAG1 and RAG2, which are expressed during lymphocyte development in bone marrow and thymus. Prompted by studies reporting re-expression of the RAGs in germinal center B cells, the expression of RAGs and terminal deoxynucleotidyl transferase (TdT) in human lymphoid tissues ... More
Rare detection of phenotypically immature lymphocytes in Hashimoto thyroiditis and rheumatoid arthritis.
AuthorsSening W, Lisner R, Niedobitek G,
JournalJ Autoimmun
PubMed ID14987743
It has been suggested that recombination activating gene (RAG)-dependent revision of the immunoglobulin genes in germinal centres may contribute to local production of autoantibodies in Hashimoto thyroiditis (HT) and rheumatoid arthritis (RA). To test this hypothesis we examined HT and RA tissues for expression of RAG and terminal deoxynucleotidyl transferase ... More