Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications.
AuthorsKwon MJ, Kim SS, Choi YL, Jung HS, Balch C, Kim SH, Song YS, Marquez VE, Nephew KP, Shin YK,
JournalCarcinogenesis
PubMed ID20053926
'Unlike epigenetic silencing of tumor suppressor genes, the role of epigenetic derepression of cancer-promoting genes or oncogenes in carcinogenesis remains less well understood. The tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer and their overexpression was previously reported to promote the migration and invasion of ovarian ... More
Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours.
AuthorsSoini Y
JournalHistopathology
PubMed ID15842637
Claudins are adhesion molecules present in tight junctions. To evaluate their usefulness as differentiation markers claudins 1, 2, 3, 4, 5 and 7 were studied in 116 epithelial and 92 non-epithelial tumours. ... More
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
AuthorsHintsala HR, Siponen M, Haapasaari KM, Karihtala P, Soini Y,
Journal
PubMed ID24294371
Claudins are tight junction proteins regulating the paracellular permeability of cell layers. We investigated the expression of claudins 1, 2, 3, 4, 5 and 7 in a sample set consisting of a total of 93 cases representing normal skin, actinic keratoses and squamous cell carcinomas of the skin. There were ... More
Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.
The heterogeneous nature of mammary tumours may arise from different initiating genetic lesions occurring in distinct cells of origin. Here, we generated mice in which Brca2, Pten and p53 were depleted in either basal mammary epithelial cells or luminal oestrogen receptor (ER)-negative cells. Basal cell-origin tumours displayed similar histological phenotypes, ... More
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
AuthorsLécuyer H, Nassif X, Coureuil M
JournalInfect Immun
PubMed ID22064711
Following adhesion on brain microvasculature, Neisseria meningitidis is able to cross the blood-brain barrier (BBB) by recruiting the polarity complex and the cell junction proteins, thus allowing the opening of the paracellular route. This feature is the consequence of the activation by the type IV pili of the ß2-adrenergic receptor/ß-arrestin ... More