Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells.
AuthorsMee CJ, Harris HJ, Farquhar MJ, Wilson G, Reynolds G, Davis C, van IJzendoorn SC, Balfe P, McKeating JA,
JournalJ Virol
PubMed ID19357163
'The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes, which are highly polarized with tight junctions (TJ) separating their basolateral and apical domains. HepG2 cells develop polarity over time, resulting in the formation and remodeling of bile canalicular (BC) structures. HepG2 cells expressing CD81 provide ... More
Tight junction proteins vary in the choroid plexus of ewes according to photoperiod.
AuthorsLagaraine C, Skipor J, Szczepkowska A, Dufourny L, Thiery JC
JournalBrain Res
PubMed ID21529785
'Sheep from temperate latitudes exhibit seasonal variations in many physiological functions such as reproduction, food intake, body weight, and pelage growth. Majority of seasonal changes are controlled by the annual photoperiodic cycle and melatonin secretion. For reproduction, the resulting key event is a modulation of the negative feedback of steroids ... More
Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours.
AuthorsSoini Y
JournalHistopathology
PubMed ID15842637
Claudins are adhesion molecules present in tight junctions. To evaluate their usefulness as differentiation markers claudins 1, 2, 3, 4, 5 and 7 were studied in 116 epithelial and 92 non-epithelial tumours. ... More
Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.
AuthorsHornick JL, Fletcher CD,
JournalAm J Surg Pathol
PubMed ID15958849
Benign peripheral nerve sheath tumors are uncommon in the gastrointestinal tract, and perineuriomas have not previously been reported to occur at this anatomic location. In this study, we analyzed the clinicopathologic and immunohistochemical features of 10 perineuriomas arising in the intestine. Eight patients were female and 2 male (median age, ... More
Claudin-1, -2, -3, -4, -7, -8, and -10 protein expression in biliary tract cancers.
AuthorsNémeth Z, Szász AM, Tátrai P, Németh J, Gyorffy H, Somorácz A, Szíjártó A, Kupcsulik P, Kiss A, Schaff Z,
JournalJ Histochem Cytochem
PubMed ID18854598
Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play important roles in maintaining epithelial cell polarity, controlling paracellular diffusion, and regulating cell growth and differentiation. The expression profile of claudins has been extensively characterized, but few reports exist ... More
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
AuthorsHintsala HR, Siponen M, Haapasaari KM, Karihtala P, Soini Y,
Journal
PubMed ID24294371
Claudins are tight junction proteins regulating the paracellular permeability of cell layers. We investigated the expression of claudins 1, 2, 3, 4, 5 and 7 in a sample set consisting of a total of 93 cases representing normal skin, actinic keratoses and squamous cell carcinomas of the skin. There were ... More
Tight junction protein claudin-4 is modulated via ?Np63 in human keratinocytes.
AuthorsKubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S
Journal
PubMed ID25449274
In the epidermis, tight junction (TJ) structure is specifically located in the stratum granulosum, where the expression of ?Np63, a p53 family transcription factor, is attenuated. Since the relationship between ?Np63 and barrier function has not been fully uncovered, we assessed expression profiles of TJ proteins in skin tissues and ... More
Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.
AuthorsKwon Y, Cukierman E, Godwin AK
JournalPLoS One
PubMed ID21526198
Epithelial ovarian cancer is an aggressive and deadly disease and understanding its invasion mechanisms is critical for its treatment. We sought to study the penetration/invasion of ovarian tumor cells into extracellular matrices (ECMs) using a fibroblast-derived three-dimensional (3D) culture model and time-lapse and confocal imaging. Twelve ovarian tumor cells were ... More
Slug is associated with poor survival in squamous cell carcinoma of the lung.
AuthorsMerikallio H, T TT, Pääkkö P, Mäkitaro R, Kaarteenaho R, Lehtonen S, Salo S, Salo T, Harju T, Soini Y
Journal
PubMed ID25337226
We investigated the expression of slug in a large set of lung squamous and adenocarcinomas to determine common or dissimilar features in its expression in these two most common forms of lung cancer. To investigate slug related tumor spread we studied the expression of vimentin, claudin 1, MMP2 and MMP9 ... More