Differential expression of claudin tight junction proteins in the human cortical nephron.
AuthorsKirk A, Campbell S, Bass P, Mason J, Collins J
JournalNephrol Dial Transplant
PubMed ID20124215
In renal tubules, paracellular permeability is tightly controlled to facilitate solute absorption and urinary concentration and is regulated by tight junctions, which incorporate claudin proteins. There is very limited information confirming the localization of these proteins in the human renal cortex. Most data is inferred from mouse, bovine and rabbit ... More
Integrin Beta 1 suppresses multilayering of a simple epithelium.
AuthorsChen J, Krasnow MA,
JournalPLoS One
PubMed ID23285215
Epithelia are classified as either simple, a single cell layer thick, or stratified (multilayered). Stratified epithelia arise from simple epithelia during development, and transcription factor p63 functions as a key positive regulator of epidermal stratification. Here we show that deletion of integrin beta 1 (Itgb1) in the developing mouse airway ... More