Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy.
AuthorsHe J, Yu JJ, Xu Q, Wang L, Zheng JZ, Liu LZ, Jiang BH
Journal
PubMed ID25650716
'Cisplatin is commonly used in ovarian cancer treatment by inducing apoptosis in cancer cells as a result of lethal DNA damage. However, the intrinsic and acquired resistance to cisplatin in cancer cells remains a big challenge for improving overall survival. The cyto-protective functions of autophagy in cancer cells have been ... More
Tristetraprolin suppresses the EMT through the down-regulation of Twist1 and Snail1 in cancer cells.
AuthorsYoon NA, Jo HG, Lee UH, Park JH, Yoon JE, Ryu J, Kang SS, Min YJ, Ju SA, Seo EH, Huh IY, Lee BJ, Park JW, Cho WJ
JournalOncotarget
PubMed ID26840564
Inhibition of epithelial-mesenchymal transition (EMT)-inducing transcription factors Twist and Snail prevents tumor metastasis but enhances metastatic growth. Here, we report an unexpected role of a tumor suppressor tristetraprolin (TTP) in inhibiting Twist and Snail without enhancing cellular proliferation. TTP bound to the AU-rich element (ARE) within the mRNA 3'UTRs of ... More
Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis.
AuthorsYang C, Li J, Yu L, Zhang Z, Xu F, Jiang L, Zhou X, He S
JournalCell Death Dis
PubMed ID28981102
Receptor-interacting kinase-3 (RIP3) is a key regulator of necroptosis. It has been shown that the expression of RIP3 is silenced in most cancer cells and tissues due to genomic methylation. However, the regulatory mechanisms controlling RIP3 expression in cancer cells have not been fully elucidated. Here, we report that Sp1, ... More
Human rickettsial pathogen modulates arthropod organic anion transporting polypeptide and tryptophan pathway for its survival in ticks.
AuthorsTaank V, Dutta S, Dasgupta A, Steeves TK, Fish D, Anderson JF, Sultana H, Neelakanta G
JournalSci Rep
PubMed ID29038575
The black-legged tick Ixodes scapularis transmits the human anaplasmosis agent, Anaplasma phagocytophilum. In this study, we show that A. phagocytophilum specifically up-regulates I. scapularis organic anion transporting polypeptide, isoatp4056 and kynurenine amino transferase (kat), a gene involved in the production of tryptophan metabolite xanthurenic acid (XA), for its survival in ... More
Curcumin Exerted Neuroprotection against Ozone-Induced Oxidative Damage and Decreased NF-
Ozone is a harmful tropospheric pollutant, causing the formation of reactive oxygen and nitrogen species that lead to oxidative damage in living beings. NF-
The LiaFSR and BsrXRS Systems Contribute to Bile Salt Resistance in
AuthorsZhou L, Wang L, Tian P, Bao T, Li L, Zhao X
JournalFront Microbiol
PubMed ID31134041
Two-component systems (TCSs) are dominant regulating components in bacteria for responding to environmental stimuli. However, little information is available on how TCSs in
Domain-specific expression of meristematic genes is defined by the LITTLE ZIPPER protein DTM in tomato.
AuthorsXu Q, Li R, Weng L, Sun Y, Li M, Xiao H
JournalCommun Biol
PubMed ID31044159
Shoot meristems, which harbor a small population of stem cells, are responsible for generating new above-ground organs in plants. The proliferation and differentiation of these stem cells is regulated by a genetic pathway involving two key meristematic genes: ... More