Study of neurotoxic intracellular calcium signalling triggered by amyloids.
AuthorsVillalobos C, Caballero E, Sanz-Blasco S, Núñez L
JournalMethods Mol Biol
PubMed ID22528098
Neurotoxicity in Alzheimer's disease (AD) is associated to dishomeostasis of intracellular Ca(2+) induced by amyloid ß peptide (Aß) species. Understanding of the effects of Aß on intracellular Ca(2+) homeostasis requires preparation of the different Aß assemblies including oligomers and fibrils and the testing of their effects on cytosolic and mitochondrial ... More