Basolateral membrane expression of a K+ channel, Kir 2.3, is directed by a cytoplasmic COOH-terminal domain.
Authors Le Maout S; Welling P A; Brejon M; Olsen O; Merot J;
JournalProc Natl Acad Sci U S A
PubMed ID11504929
'The inwardly rectifying potassium channel Kir 2.3 is specifically targeted and expressed on the basolateral membrane of certain renal epithelial cells. In the present study, the structural basis for polarized targeting was elucidated. Deletion of a unique COOH-terminal domain produced channels that were mistargeted to the apical membrane, consistent with ... More
Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay.
AuthorsCherry JJ, Evans MC, Ni J, Cuny GD, Glicksman MA, Androphy EJ
JournalJ Biomol Screen
PubMed ID22233647
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that is characterized by progressive loss of motor neuron function. It is caused by the homozygous loss of the SMN1 (survival of motor neuron 1) gene and a decrease in full-length SMN protein. SMN2 is a nearly identical homolog of SMN1 that, ... More