Homoharringtonine binds to and increases myosin-9 in myeloid leukaemia.
AuthorsZhang T, Shen S, Zhu Z, Lu S, Yin X, Zheng J, Jin J
JournalBr J Pharmacol
PubMed ID26448459
Homoharringtonine (HHT) is a natural alkaloid isolated from various Cephalotaxus species. HHT has been used to treat acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), chronic lymphocyte leukaemia and myelodysplastic syndromes. Although HHT inhibits protein synthesis and promotes apoptosis of leukaemia cells in preclinical studies, its molecular target proteins remain ... More