Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies.
AuthorsRoncato F, Rruga F, Porcù E, Casarin E, Ronca R, Maccarinelli F, Realdon N, Basso G, Alon R, Viola G, Morpurgo M
JournalNat Commun
PubMed ID30287819
'Nowadays, personalized cancer therapy relies on small molecules, monoclonal antibodies, or antibody-drug conjugates (ADC). Many nanoparticle (NP)-based drug delivery systems are also actively investigated, but their advantage over ADCs has not been demonstrated yet. Here, using the Avidin-Nucleic-Acid-Nano-Assemblies (ANANAS), a class of polyavidins multifuctionalizable with stoichiometric control, we compare quantitatively ... More