Isolation and characterization of antibody fragments selective for toxic oligomeric tau.
AuthorsTian H, Davidowitz E, Lopez P, He P, Schulz P, Moe J, Sierks MR
Journal
PubMed ID25616912
Oligomeric tau species are important in the onset and progression of Alzheimer's disease (AD), as they are neurotoxic and can propagate tau-tangle pathology. Therefore, reagents that selectively recognize different key morphologies of tau are needed to help define the role of tau in AD and related diseases. We utilized a ... More