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Invitrogen
IFN beta Monoclonal Antibody (MMHB-3)
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Product Details
214001
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
MMHB-3
Immunogen
human interferon beta
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Size-exclusion chromatography, Ion-exchange chromatography
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Specificity: Neutralizes human interferon beta. For best results in experiments involving neutralization of the anti-viral effect of human interferon beta we recommend using sheep polyclonal antibody to human interferon beta (Product # 314001).
Activity: Interferon was titrated with the use of the cytopathic effect inhibition assay, where 1 unit/mL of interferon was necessary to produce an endpoint of 50%. One neutralization unit is defined as the amount of serum required to neutralize one unit of human IFN beta to an endpoint of 50%.
Purity is >95%. Endotoxin level <1 EU/ug.
Store at -20°C for short-term use (less than 6 months). For long-term storage, aliquot and store at -70°C or below for retention of full activity, avoiding freeze/thaw cycles.
Packaged by and distributed for PBL Assay Science.
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fibroblast interferon; IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon; Interferon b; Interferon beta; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1; unnamed protein product
Gene Aliases: IFB; IFF; IFN-beta; IFNB; IFNB1
UniProt ID: (Human) P01574
Entrez Gene ID: (Human) 3456
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
negative regulation of immune system process
regulation of transcription from RNA polymerase II promoter
response to stress
defense response
immune response
humoral immune response
signal transduction
cell surface receptor signaling pathway
JAK-STAT cascade
response to virus
positive regulation of metabolic process
positive regulation of autophagy
cytokine-mediated signaling pathway
natural killer cell activation
cellular response to interferon-beta
B cell proliferation
response to exogenous dsRNA
negative regulation of viral genome replication
innate immune response
positive regulation of innate immune response
leukocyte activation
regulation of MHC class I biosynthetic process
negative regulation of T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of multicellular organismal process
defense response to virus
type I interferon signaling pathway
neuron cellular homeostasis
cellular response to dsRNA
cellular response to exogenous dsRNA
receptor signaling pathway via STAT
cellular response to virus
negative regulation of Lewy body formation
antiviral innate immune response
positive regulation of protein localization to nucleus
negative regulation of T-helper 2 cell cytokine production
positive regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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