AuthorsWouters K, Deleye Y, Hannou SA, Vanhoutte J, Maréchal X, Coisne A, Tagzirt M, Derudas B, Bouchaert E, Duhem C, Vallez E, Schalkwijk CG, Pattou F, Montaigne D, Staels B, Paumelle R
JournalDiab Vasc Dis Res
PubMed ID28868898
The genomic CDKN2A/B locus, encoding p16
Progranulin in the hematopoietic compartment protects mice from atherosclerosis.
Progranulin is a circulating protein that modulates inflammation and is found in atherosclerotic lesions. Here we determined whether inflammatory cell-derived progranulin impacts atherosclerosis development.