Association of Bcr-Abl with the Proto-oncogene Vav Is Implicated in Activation of the Rac-1 Pathway.
Authors Bassermann Florian; Jahn Thomas; Miething Cornelius; Seipel Petra; Bai Ren-Yuan; Coutinho Sunita; Tybulewicz Victor L; Peschel Christian; Duyster Justus;
JournalJ Biol Chem
PubMed ID11790798
'Vav is a guanine nucleotide exchange factor for the Rho/Rac family predominantly expressed in hematopoietic cells and implicated in cell proliferation and cytoskeletal organization. The oncogenic tyrosine kinase Bcr-Abl has been shown to activate Rac-1, which is important for Bcr-Abl induced leukemogenesis. Previous studies by Matsuguchi et al. (Matsuguchi, T., ... More
Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B.
Authors Rizzo C; Califano D; Colucci-D'Amato G L; De Vita G; D'Alessio A; Dathan N A; Fusco A; Monaco C; Santelli G; Vecchio G; Santoro M; de Franciscis V;
JournalJ Biol Chem
PubMed ID8910618
Inherited activating mutations of Ret, a receptor tyrosine kinase, predispose to multiple endocrine neoplasia (MEN) types 2A and 2B and familial medullary thyroid carcinoma. To investigate the effects induced by acute stimulation of Ret, we transfected both PC12 and NIH 3T3 cells with a molecular construct in which the ligand-binding ... More
Pore-forming polypeptides of the pathogenic protozoon Naegleria fowleri.
The free-living amoeboflagellate and potential human pathogen Naegleria fowleri causes the often fatal disease primary amoebic meningoencephalitis. The molecular repertoire responsible for the cytolytic and tissue-destructive activity of this amoeboid protozoon is largely unknown. We isolated two pore-forming polypeptides from extracts of highly virulent trophozoites of N. fowleri by measuring ... More