Cell-penetrating Peptide enhanced intracellular Raman imaging and photodynamic therapy.
AuthorsFales AM, Yuan H, Vo-Dinh T
Journal
PubMed ID23659475
'We present the application of a theranostic system combining Raman imaging and the photodynamic therapy (PDT) effect. The theranostic nanoplatform was created by loading the photosensitizer, protoporphyrin IX, onto a Raman-labeled gold nanostar. A cell-penetrating peptide, TAT, enhanced intracellular accumulation of the nanoparticles in order to improve their delivery and ... More
Slow-cycling therapy-resistant cancer cells.
AuthorsMoore N, Houghton J, Lyle S
JournalStem Cells Dev
PubMed ID21973238
Tumor recurrence after chemotherapy is a major cause of patient morbidity and mortality. Recurrences are thought to be secondary to small subsets of cancer cells that are better able to survive traditional forms of chemotherapy and thus drive tumor regrowth. The ability to isolate and better characterize these therapy-resistant cells ... More