Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells.
AuthorsLi T, Dai W, Lu L.
JournalJ Biol Chem
PubMed ID12082101
'The exposure of mammalian cells to UV irradiation induces the expression of immediate early genes such as c-jun and c-fos and activates the transcription factors AP-1 and NF-kappaB. JunD is one of the three members of the Jun family and shares some functional characteristics with c-Jun. In the present study, ... More
Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells.
AuthorsXie Y, Gibbs TC, Mukhin YV, Meier KE.
JournalJ Biol Chem
PubMed ID12084719
Lysophosphatidic acid (LPA) is a lipid mediator that may play an important role in growth and survival of carcinomas. In this study, LPA production and response were characterized in two human prostate cancer (CaP) cell lines: PC-3 and Du145. Bombesin, a neuroendocrine peptide that is mitogenic for CaP cells, stimulated ... More