Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction.
AuthorsNeville-Webbe HL, Coleman RE, Holen I,
JournalBr J Cancer
PubMed ID20160726
'Aromatase inhibitors are widely used in the treatment of oestrogen receptor-positive post-menopausal breast cancer. These patients may also be receiving the bisphosphonate, zoledronic acid (ZA) to prevent bone loss or reduce skeletal morbidity in the setting of advanced disease. The potential biological interaction of these two drugs in breast cancer ... More
Isolation, cultivation and characterization of adult murine prostate stem cells.
AuthorsLukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON,
JournalNat Protoc
PubMed ID20360765
'The successful isolation and cultivation of prostate stem cells will allow us to study their unique biological properties and their application in therapeutic approaches. Here we describe step-by-step procedures on the basis of previous work in our laboratory for the harvesting of primary prostate cells from adolescent male mice by ... More