Tyrosine Phosphatase STEP Is a Tonic Brake on Induction of Long-Term Potentiation.
Authors Pelkey Kenneth A; Askalan Rand; Paul Surojit; Kalia Lorraine V; Nguyen Tri Hung; Pitcher Graham M; Salter Michael W; Lombroso Paul J;
JournalNeuron
PubMed ID11931747
'The functional roles of protein tyrosine phosphatases (PTPs) in the developed CNS have been enigmatic. Here we show that striatal enriched tyrosine phosphatase (STEP) is a component of the N-methyl-D-aspartate receptor (NMDAR) complex. Functionally, exogenous STEP depressed NMDAR single-channel activity in excised membrane patches. STEP also depressed NMDAR-mediated synaptic currents ... More