Reduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly.
AuthorsEdnie AR, Bennett ES
Journal
PubMed ID25525262
'Voltage-gated K(+) channels (Kv) are responsible for repolarizing excitable cells and can be heavily glycosylated. Cardiac Kv activity is indispensable where even minimal reductions in function can extend action potential duration, prolong QT intervals, and ultimately contribute to life-threatening arrhythmias. Diseases such as congenital disorders of glycosylation often cause significant ... More
Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy.
AuthorsKrüger A, Stier A, Fischbach A, Bürkle A, Hauser K, Mangerich A
JournalNucleic Acids Res
PubMed ID30892621
'Due to multiple domains and in part intrinsically disordered regions, structural analyses of p53 remain a challenging task, particularly in complex with DNA and other macromolecules. Here, we applied a novel attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic approach to investigate changes in secondary structure of full-length p53 induced ... More