IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
Authors Lee Kyungho; Tirasophon Witoon; Shen Xiaohua; Michalak Marek; Prywes Ron; Okada Tetsuya; Yoshida Hiderou; Mori Kazutoshi; Kaufman Randal J;
JournalGenes Dev
PubMed ID11850408
'All eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by signaling an adaptive pathway termed the unfolded protein response (UPR). In yeast, a type-I ER transmembrane protein kinase, Ire1p, is the proximal sensor of unfolded proteins in the ER lumen that initiates an unconventional ... More
c-Src-dependent transcriptional activation of TFII-I.
Authors Cheriyath Venugopalan; Desgranges Zana Patrick; Roy Ananda L;
JournalJ Biol Chem
PubMed ID11934902
'TFII-I is a multifunctional transcription factor that is also involved in signal transduction. Here we show that TFII-I undergoes a c-Src-dependent tyrosine phosphorylation on tyrosine residues 248 and 611 and translocates to the nucleus in response to growth factor signaling. Tyrosine-phosphorylated nuclear TFII-I activates a stably integrated c-fos reporter gene. ... More