Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro.
AuthorsCourtemanche C, Elson-Schwab I, Mashiyama ST, Kerry N, Ames BN,
JournalJ Immunol
PubMed ID15322179
'Folate is required for one-carbon transfer reactions and the formation of purines and pyrimidines for DNA and RNA synthesis. Deficiency of folate can lead to many clinical abnormalities, including macrocytic anemia, cardiovascular diseases, birth defects, and carcinogenesis. The nucleotide imbalance due to folate deficiency causes cell cycle arrest in the ... More