CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis.
AuthorsWu Q, Moeller HB, Stevens DA, Sanchez-Hodge R, Childers G, Kortenoeven MLA, Cheng L, Rosenbaek LL, Rubel C, Patterson C, Pisitkun T, Schisler JC, Fenton RA
JournalJ Am Soc Nephrol
PubMed ID29242247
'The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CCD) is highlighted by various water and electrolyte disorders that arise when the unique transport properties of these segments are disturbed. Despite this critical role, little is known about which proteins have a regulatory role in these ... More
Gi Protein Modulation of the Potassium Channel TASK-2 Mediates Vesicle Osmotic Swelling to Facilitate the Fusion of Aquaporin-2 Water Channel Containing Vesicles.
AuthorsCentrone M, De Santo MP, Nicotera I, Labate C, Ranieri M, Di Mise A, Mola MG, Mastrodonato M, Elliani R, Barberi R, Formoso V, Tamma G, Valenti G
JournalCells
PubMed ID30572630
Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first example that non-secretory ... More
Defining the Specificity of Carbohydrate-Protein Interactions by Quantifying Functional Group Contributions.
AuthorsSood A, Gerlits OO, Ji Y, Bovin NV, Coates L, Woods RJ
JournalJ Chem Inf Model
PubMed ID30086239
Protein-carbohydrate interactions are significant in a wide range of biological processes, disruption of which has been implicated in many different diseases. The capability of glycan-binding proteins (GBPs) to specifically bind to the corresponding glycans allows GBPs to be utilized in glycan biomarker detection or conversely to serve as targets for ... More
The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance.
AuthorsMurali SK, Aroankins TS, Moeller HB, Fenton RA
JournalCells
PubMed ID30901874
Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis. VP effects on AQP2 occur via long-term alterations in AQP2 abundance and short-term changes in AQP2 localization. Several of the effects of VP on ... More