An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.
AuthorsRomani L, Mencacci A, Cenci E, Del Sero G, Bistoni F, Puccetti P,
JournalJ Immunol
PubMed ID9036985
Granulocytes may serve immunoregulatory and effector roles in different limbs of the immune response to infection. Using live vaccine strain or virulent challenge in mucosal or systemic infection of mice with Candida albicans, we examined the effect of mAb-mediated depletion of neutrophils on the course of primary and secondary challenge ... More
Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.
AuthorsSad S, Mosmann TR,
JournalJ Immunol
PubMed ID7930573
Immunocompetent T lymphocytes in peripheral tissues mainly secrete IL-2 when first stimulated, whereas effector T lymphocytes generated during an immune response secrete different cytokine patterns, such as the Th1, Th2, or other phenotypes displayed by in vitro T cell clones. In this paper, we have examined whether the cell populations ... More
Gamma delta T cells in normal spleen assist immunized alpha beta T cells in the adoptive cell transfer of contact sensitivity. Effect of Bordetella pertussis, cyclophosphamide, and antibodies to determinants on suppressor cells.
AuthorsAskenase PW, Szczepanik M, Ptak M, Paliwal V, Ptak W,
JournalJ Immunol
PubMed ID7706708
Our prior studies showed that gamma delta T cells were required to assist alpha beta T cells in the successful adoptive cell transfer of contact sensitivity (CS) responsiveness. These TCR-gamma delta+ regulatory T cells in immune spleen and lymph node were CD3+, CD4-, CD8+, nonantigen-specific, and non-MHC-restricted. In the current ... More