On the nature of proteinuria with acute renal injury in patients with chronic kidney disease.
AuthorsAgarwal R,
JournalAm J Physiol Renal Physiol
PubMed ID15467003
'Albuminuria is an excellent marker of cardiovascular and renal prognosis. Commercially available tests of immunodetectable albumin in the urine may not identify posttranslationally modified albumin that makes it undetectable to antibodies. Also, it is unclear whether albumin is degraded to smaller fragments, such as through proteolysis, in the course of ... More
Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells.
AuthorsFarhat R, Goueslain L, Wychowski C, Belouzard S, Fénéant L, Jackson CL, Dubuisson J, Rouillé Y,
Journal
PubMed ID24058576
Recent reports indicate that the replication of hepatitis C virus (HCV) depends on the GBF1-Arf1-COP-I pathway. We generated Huh-7-derived cell lines resistant to brefeldin A (BFA), which is an inhibitor of this pathway. The resistant cell lines could be sorted into two phenotypes regarding BFA-induced toxicity, inhibition of albumin secretion, ... More
Subproteomic analysis of metal-interacting proteins in human B cells.
AuthorsHeiss K, Junkes C, Guerreiro N, Swamy M, Camacho-Carvajal MM, Schamel WW, Haidl ID, Wild D, Weltzien HU, Thierse HJ,
JournalProteomics
PubMed ID16097032
Metal-protein interactions are vitally important in all living organisms. Metalloproteins, including structural proteins and metabolic enzymes, participate in energy transfer and redox reactions or act as metallochaperones in metal trafficking. Among metal-associated diseases, T cell mediated allergy to nickel (Ni) represents the most common form of human contact hypersensitivity. With ... More
Acute cellular rejection of human renal tissue by adoptive transfer of allogeneic human peripheral blood mononuclear cells into chimeric rats: sequential gene expression of cytokines, chemokines and cytolytic effector molecules, and their regulation by CTLA-4-Ig.
AuthorsDekel B, Böcher WO, Marcus H, Yussim A, Reisner Y,
JournalInt Immunol
PubMed ID10508185
T(h)1- and T(h)2-related cytokines (IFN-gamma, IL-2, IL-4, IL-10), beta-chemokines (RANTES, macrophage inflammatory protein-1beta) and their receptor [chemotatic cytokine receptor (CCR) 5], and the cytolytic effector molecule [Fas ligand (FasL)] play an essential role in regulating and co-ordinating acute renal allograft rejection. A chimeric model of acute cellular rejection which involves ... More