High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner.
Authors Li Xiang-An; Titlow William B; Jackson Brian A; Giltiay Nathalia; Nikolova-Karakashian Mariana; Uittenbogaard Annette; Smart Eric J;
JournalJ Biol Chem
PubMed ID11792700
Recently it has been demonstrated that high density lipoprotein (HDL) binding to scavenger receptors, class B, type I (SR-BI) stimulates endothelial nitric-oxide synthase (eNOS) activity. In the present studies we used a Chinese hamster ovary cell system and a human microvascular endothelial cell line to confirm that HDL stimulates eNOS ... More