Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors.
AuthorsFine SW, Li M
JournalAm J Clin Pathol
PubMed ID12579997
'Granular cell tumors (GCTs) typically express S-100 protein, which has been used as a marker in differential diagnosis. Calretinin, a calcium-binding protein related structurally to S-100, and inhibin, a polypeptide hormone secreted primarily by ovarian granulosa cells and testicular Sertoli cells and functioning as an inhibitor for pituitary follicle-stimulating hormone ... More
Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression.
AuthorsAllen SM, Florell SR, Hanks AN, Alexander A, Diedrich MJ, Altieri DC, Grossman D,
JournalCancer Res
PubMed ID12566297
'Induction of cutaneous squamous cell carcinoma (SCC) in mice, by topical chemical [9,10-dimethylbenzanthracene (DMBA) and phorbol 12-myristate 13-acetate (PMA)] application, is a multistep process involving papilloma formation and progression to carcinoma. We have generated a transgenic (Tg) mouse [keratin-14 (K14)-survivin] with skin expression of survivin, an inhibitor of apoptosis expressed ... More
Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder.
AuthorsD'Andrea MR, Saban MR, Nguyen NB, Andrade-Gordon P, Saban R
JournalAm J Pathol
PubMed ID12598324
Inflammation underlines all major bladder pathologies and represents a defense reaction to injury involving a mandatory participation of mast cells and sensory nerves. Mast cells are particularly frequent in close proximity to epithelial surfaces where they are strategically located in the bladder and release their mediators in response to inflammation. ... More