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Invitrogen
GluR2 Monoclonal Antibody (6C4)
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FIGURE: 1 / 20
GluR2 Antibody (32-0300) in ICC/IF
Immunofluorescence analysis of GluR2 was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with GluR2 (6C4) Mouse Monoclonal Antibody (Product # 32-0300) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28... View More
Product Details
32-0300
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
6C4
Immunogen
Fusion protein containing amino acids 175-430 from the N-terminal region of GluR2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMPA receptor subunit GluA2; AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; GluR2; glutamate receptor; Glutamate receptor 2; glutamate receptor B; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943; unnamed protein product
Gene Aliases: GluA2; Glur-2; GluR-B; GluR-K2; GLUR2; GLURB; GRIA2; HBGR2; NEDLIB
UniProt ID: (Human) P42262, (Rat) P19491
Entrez Gene ID: (Human) 2891, (Mouse) 14800, (Rat) 29627
beta-amyloid binding
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
protein binding
ligand-gated ion channel activity
signaling receptor activity
ligand-gated monoatomic cation channel activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
receptor activity
extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
calcium channel regulator activity
transmembrane signal receptor
ion transport
signal transduction
chemical synaptic transmission
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
modulation of synaptic transmission
regulation of postsynaptic membrane potential
cation transmembrane transport
regulation of receptor recycling
transport
receptor internalization
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to lithium ion
response to fungicide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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