Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinase.
AuthorsSvedine S, Wang T, Halaban R, Hebert DN,
JournalJ Cell Sci
PubMed ID15161941
The endoplasmic reticulum (ER) quality-control machinery maintains the fidelity of the maturation process by sorting aberrant proteins for ER-associated protein degradation (ERAD), a process requiring retrotranslocation from the ER lumen to the cytosol and degradation by the proteasome. Here, we assessed the role of N-linked glycans in ERAD by monitoring ... More