Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling.
AuthorsGiordano TJ, Kuick R, Else T, Gauger PG, Vinco M, Bauersfeld J, Sanders D, Thomas DG, Doherty G, Hammer G,
JournalClin Cancer Res
PubMed ID19147773
'Our understanding of adrenocortical carcinoma (ACC) has improved considerably, yet many unanswered questions remain. For instance, can molecular subtypes of ACC be identified? If so, what is their underlying pathogenetic basis and do they possess clinical significance? We did a whole genome gene expression study of a large cohort of ... More
Suppression of apoptosis by PIF1 helicase in human tumor cells.
AuthorsGagou ME, Ganesh A, Thompson R, Phear G, Sanders C, Meuth M,
JournalCancer Res
PubMed ID21616935
Defining the processes that sustain telomere maintenance is critical to our understanding of cancer and longevity. PIF1 is a nonprocessive 5'->3' human DNA helicase that exhibits broad substrate specificity. In vitro studies have implicated PIF1 in maintaining telomeres and processing stalled DNA replication forks, but disruption of the murine Pif1 ... More