Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion.
AuthorsWada K, Nakajima A, Takahashi H, Yoneda M, Fujisawa N, Ohsawa E, Kadowaki T, Kubota N, Terauchi Y, Matsuhashi N, Saubermann LJ, Nakajima N, Blumberg RS,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID15246971
'Acute gastric mucosal lesions (AGMLs) are an important cause of gastrointestinal bleeding. Herein, we demonstrate that peroxisome proliferator-activated receptor-gamma (PPARgamma), a member of a nuclear receptor family, functions as an endogenous anti-inflammatory pathway in a murine model of AGML induced by ischemia-reperfusion (I/R). Treatment with specific PPARgamma ligands such as ... More
Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins.
AuthorsIrie Y, Saeki M, Kamisaki Y, Martin E, Murad F,
JournalProc Natl Acad Sci U S A
PubMed ID12719531
Several reports have described an activity that modifies nitrotyrosine-containing proteins and their immunoreactivity to nitrotyrosine Abs. Without knowing the product of the reaction, this new activity has been called a ... More
Role for complement in mediating intestinal nitric oxide synthase-2 and superoxide dismutase expression.
AuthorsMontalto MC, Hart ML, Jordan JE, Wada K, Stahl GL,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID12637249
Inducible nitric oxide synthase (iNOS) and superoxide dismutase (SOD) play an important role in the pathology of ischemia-reperfusion. This study sought to determine if the proinflammatory effects of complement modulate iNOS and SOD in the rat after gastrointestinal ischemia and reperfusion (GI/R). An inhibitory or noninhibitory anti-complement component 5 (C5) ... More